Synthesis of New7-ethyl-4-methyl-2-Quinolone Derivatives

Authors

  • Luma S Ahamed Department of Chemistry, College of Science, University of Baghdad, Baghdad, Iraq
  • Rana Abid Ali Department of Chemistry, College of Science, University of Baghdad, Baghdad, Iraq
  • Rana S Ahmed Department of pharmacy, Al Israa University college, Baghdad, Iraq
  • Mohammed R Ahamad Department of Chemistry, College of Science, University of Baghdad, Baghdad, Iraq
  • Redha I Al-Bayati Department of Chemistry, College of Science, Al-Mustansirya University, Baghdad, Iraq

Keywords:

non

Abstract

A series of new derivatives of 7-ethyl-4-methyl quinoline-2-one were synthesized, by cyclization reaction of m-ethyl phenol with ethylacetoacetate in the presence of sulfuric acid to yield 7-ethyl-4-methyl coumarin, which was chosen as the starting material and it was treated with hydrazine hydrate 80% to give a new compound 1-amino-4 methyl-7- ethyl quinoline-2(1H)-one. The later compound introduced in different synthetic methods to produce new 4-methyl-7-ethyl-2-qunolone derivatives containing amide, imine, and acetylenic groups (L4-L10). Synthesized compounds were characterized by FT-IR, 1H-NMR, 13C-NMR spectra and by measuring some of their physical properties.

Published

2019-01-10

Issue

Section

Articles

How to Cite

(1)
Synthesis of New7-Ethyl-4-Methyl-2-Quinolone Derivatives. ANJS 2019, No. 2, 30-37.