Synthesis of Some Schiff's Bases Containing 1,3,4-Thiadiazole Ring and Their Properties as Antioxidants

Abstract

A series of Schiff's bases containing 1,3,4-thiadiazole (2,5-di(N-substitutedbenzylideneamino)-
1,3,4-thiadiazole) were prepared through the reaction of thiosemicarbazide with chloro cyanide.
The product was directly reacted with benzaldehyde and substituted benzaldehydes. The synthetic
compounds (0-10) were identified using the analytical and spectral means. The antioxidant
properties were measured of the prepared compounds using the metal ions (Fe+3, Cu+2), and
Ferrozine and 2,9-dimethyl-1,10-phenanthroline (neocuproine). The results showed that the
compound no. 5 [2,5-di(N-(4-hydroxybenzylideneamino)-1,3,4-thiadiazole] reveals the highest
antioxidant activity through this work.