Design and Synthesis of New Mefenamic Acid Derivatives as Anti-Inflammatory Agents

Authors

  • Nadeem A Abdul-Razzak Department of Pharmaceutical Chemistry, College of Pharmacy, University of Baghdad, Baghdad, Iraq.

Keywords:

Nonsteriodal anti-inflammatory drugs (NSAID), mefenamic acid derivatives, cyclooxygenase-1(cox-1), cyclooxygenase-2(cox-2)

Abstract

This study includes design and synthesis of new non-steroidal anti inflammatory agents (NSAIDs) with expected cyclooxygenase-2 (COX-2) selective inhibition to achieve better activity and low gastric side effects. Two mefenamic acid derivatives were designed and synthesized as potential NSAIDs. In vivo acute anti-inflammatory effect of the synthesized agents (compound 2and 3) was evaluated in the rat using egg-white induced paw edema model of inflammation. Preliminary pharmacological study revealed that compound 2and 3 produced a significant reduction in paw edema with respect to the effect of propylene glycol 50% v/v (control group), moreover compound 2 exhibited comparable anti-inflammatory effect to that of aspirin after 120 and 210 minutes and compound 3 has less anti-inflammatory effect, which encourages the continuation of the search to identify their selectivity toward COX-2 isoenzymes.

 

Published

2018-07-16

Issue

Section

Articles

How to Cite

(1)
Design and Synthesis of New Mefenamic Acid Derivatives As Anti-Inflammatory Agents. ANJS 2018, 14 (4), 38-44.