Synthesis, Characterization and Cytotoxic Activity of Some Pyrimidine Derivatives

Authors

  • Salman Ali Ahmed Department of Chemistry, College of Science, University of Al-Nahrain.
  • Tamara Sami Naji Department of Chemistry, College of Science, Al-Nahrain University, Baghdad-Iraq
  • Farooq Ibrahem Mohammad Biotechnology Research Center, Al- Nahrain University, Baghdad-Iraq.

Keywords:

Pyrimidine derivatives, Cytotoxic activity, Human cancer cell line

Abstract

Synthesis of some pyrimidine derivatives which plays an important role in the medicinal chemistry because it possesses promising cytotoxic activity. The synthesized compounds were characterized by UV-Visible and FT-IR spectral data. Some of the new compounds were evaluated for their potential cytotoxicity against two different human cancer cell lines HepG2 (hepatocellular carcinoma) and MCF-7 (breast adenocarcinoma) in vitro, using Neutral Red and MTT assays. The synthesized compounds were active against two cell lines under study and a toxic effect was clear with a significant difference at the level of probability (p< 0.0001) and this effect was contrasted among different concentrations for each synthesized compound.

Author Biography

  • Salman Ali Ahmed, Department of Chemistry, College of Science, University of Al-Nahrain.

    Salman Ali Ahmed*
    ,

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Published

2013-06-01

Issue

Vol. 16 No. 2 (2013): June

Section

Articles

How to Cite

[1]
“Synthesis, Characterization and Cytotoxic Activity of Some Pyrimidine Derivatives”, ANJS, vol. 16, no. 2, pp. 84–92, Jun. 2013, Accessed: Apr. 20, 2024. [Online]. Available: https://anjs.edu.iq/index.php/anjs/article/view/668