Fabrication of Ultrasensitive Aluminum Oxide Nanoparticle Sensors for Potentiometric Determination of Ondansetron Dihydrate Hydrochloride in Pure and Pharmaceutical Forms

Authors

  • Dheaa Shamikh Zgear Higher Institute of Forensic Sciences, Al-Nahrain University, Jadiriya, Baghdad, Iraq.
  • Muataz Ali Higher Institute of Forensic Sciences, Al-Nahrain University, Jadiriya, Baghdad, Iraq. https://orcid.org/0000-0001-6825-9519
  • Amina M. Abaas Higher Institute of Forensic Sciences, Al-Nahrain University, Jadiriya, Baghdad, Iraq.
  • Rami A. Abdel-Rahem Department of Chemistry, Faculty of Arts and Sciences, University of Petra, Amman, Jordan.

DOI:

https://doi.org/10.22401/anjs.29.3.4212

Keywords:

Ion-selective membrane, Phosphomolybdic acid, Coated-wire electrode, Quality control.

Abstract

A highly precise potentiometric method for trace determination of Ondansetron dihydrate hydrochloride (OND) has been developed and established. A highly sensitive sensor of coated wire modified with aluminum oxide (Al2O3) was developed by incorporating trace amounts of (OND) with the ion-pairing reagent phosphomolybdic acid (PMA). Under the test conditions, the sensor exhibited a near-Nernstian response towards the drug over a linear range of 1.0×10-10 to 1.0×10-2 mol L-1 with limit of detection of 5.0x10-11 mol L-1 and slope of +59.30±0.05 mV decade-1 for (OND-PMA) coated wire sensor. The potentiometric sensor electrode showed stability up to 65 days and fast responsive time of 14 s. However, the developed potentiometric sensor for OND showed high selectivity to the mentioned drug in presence of various inorganic and some pharmaceutical species. The sensor response remained constant in a suitable potential at various pH from 2.5 to 9.0. Statistical analysis confirms that this potentiometric method is relatively very accurate and reproducible. The developed procedure was successfully applied to measure OND levels in both pure form and many commercial drug samples.

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Published

2026-09-15

Issue

Vol. 29 No. 3 (2026): September 2026

Section

Chemistry

License

Copyright (c) 2026 Dheaa Shamikh Zgear, Muataz Ali, Amina M. Abaas, Rami A. Abdel-Rahem

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

(1)
Shamikh Zgear, D. .; Ali, M.; M. Abaas, A. .; A. Abdel-Rahem, R. . Fabrication of Ultrasensitive Aluminum Oxide Nanoparticle Sensors for Potentiometric Determination of Ondansetron Dihydrate Hydrochloride in Pure and Pharmaceutical Forms. Al-Nahrain J. Sci. 2026, 29 (3), 26-36. https://doi.org/10.22401/anjs.29.3.4212.