Preparation of Some 1,2,4-Triazol Schiff Bases as Urease Inhibitors and Study Their Effect on Proteus Mirabilis Bacteria

Authors

  • Zahraa A Turky Department of Chemistry, College of Science, Al-Nahrain University, Baghdad-Iraq.
  • Salman A Ahmed Department of Chemistry, College of Science, Al-Nahrain University, Baghdad-Iraq.

Keywords:

triazol ring, triazol Schiff base, urease inhibitors

Abstract

The basic nucleus 4-(amino)-5-phenyl-l-4H-1,2,4-triazole-3-thiol was prepared by cyclisation of potassium dithiocarbazinate with hydrazine hydrate using ethanol as solvent under reflux condition for 3-4 hrs.. The compound which has been synthesized successfully was subjected to addition reaction with different aldehydes to synthesize Schiff bases. The compounds were confirmed by[ physical parameters (solubility, melting point),1H nuclear magnetic resonance (1HNMR)and spectroscopic methods (FTIR)]. All the synthesized compounds were screened for their urease inhibition. Some compounds showed excellent urease inhibition activity.

 

Published

2018-06-24

Issue

Section

Articles

How to Cite

(1)
Preparation of Some 1,2,4-Triazol Schiff Bases As Urease Inhibitors and Study Their Effect on Proteus Mirabilis Bacteria. ANJS 2018, 17 (4), 44-50.