Preparation of Some 1,2,4-Triazol Schiff Bases as Urease Inhibitors and Study Their Effect on Proteus Mirabilis Bacteria
Keywords:
triazol ring, triazol Schiff base, urease inhibitors
Abstract
The basic nucleus 4-(amino)-5-phenyl-l-4H-1,2,4-triazole-3-thiol was prepared by cyclisation of potassium dithiocarbazinate with hydrazine hydrate using ethanol as solvent under reflux condition for 3-4 hrs.. The compound which has been synthesized successfully was subjected to addition reaction with different aldehydes to synthesize Schiff bases. The compounds were confirmed by[ physical parameters (solubility, melting point),1H nuclear magnetic resonance (1HNMR)and spectroscopic methods (FTIR)]. All the synthesized compounds were screened for their urease inhibition. Some compounds showed excellent urease inhibition activity.
Published
2018-06-24
How to Cite
Turky, Z. A., & Ahmed, S. A. (2018). Preparation of Some 1,2,4-Triazol Schiff Bases as Urease Inhibitors and Study Their Effect on Proteus Mirabilis Bacteria. Al-Nahrain Journal of Science, 17(4), 44-50. Retrieved from https://anjs.edu.iq/index.php/anjs/article/view/376
Section
Articles
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