Thermodynamic Studies for the Interaction of Some Anticoagulant Drugs with Albumin

Authors

  • Elham M Al-Rufaie Department of Chemistry, College of Science, Baghdad University
  • Zahraa H Al-Shareefi Division of Basic sciences, College of Agriculture, Baghdad University

Keywords:

Albumin interaction, Anticoagulant drugs, thermodynamic parameters

Abstract

Fluorescence spectroscopy in combination with UV- vis absorption spectroscopy was employed to investigate the binding of some important anticoagulant drugs warfarin, heparin and aspirin to human serum albumin under physiological conditions. Scatchard equation provide a measure of the binding affinity between these three drugs individually and albumin. The results of thermodynamic parameters ∆G, ∆H, and ∆S at three different temperatures indicate that the hydrophobic interaction plays a major role for the interaction between each of these drugs and albumin.

 

Author Biography

  • Elham M Al-Rufaie, Department of Chemistry, College of Science, Baghdad University



Published

2018-06-01

Issue

Section

Articles

How to Cite

[1]
“Thermodynamic Studies for the Interaction of Some Anticoagulant Drugs with Albumin”, ANJS, vol. 18, no. 1, pp. 20–27, Jun. 2018, Accessed: Mar. 29, 2024. [Online]. Available: https://anjs.edu.iq/index.php/anjs/article/view/345