Silver loaded pectin nanoparticles and their anticancer activity
Keywords:
Pectin , Cancer Therapy , AgNPs , AgNPs/pectinAbstract
A plant-based heteropolysaccharide is recognized for its biocompatibility and biodegradability, making it a promising candidate for green synthesis as a stabilizing agent in the formation of metallic nanostructure. Despite this, Pectin islargely overlooked in the biological industry for MNP production, with no clear reason for its underutilization. A simple and affordable approach for creating Silver Nano products (Ag NPs) have devised by means of citrus pectin forboth a diminishing and stabilizing agent. The Ag NPs have been analyzed through UV-vis, TEM, XRD, and FTIR techniques. The findings reveal that the Ag NPs are spherical, with a consistent, scale of 10 nanometers besides the outstanding dispersion. Moreover, the Ag NPs showed strong anticancer properties. Employing citrus pectin in the synthesis of Ag NPs offers a potential new avenue regarding the effective use of citrus byproducts.
References
Bahadar H, Maqbool F, Niaz K, Abdollahi M. 2016. Toxicity of nanoparticles and an overview of current experimental models. Iran Biomed J. 20(1):1–11. [PubMed], [Google Scholar].
Balachandran YL, Girija S, Selvakumar R, Tongpim S, Gutleb AC, Suriyanarayanan S. 2013. Differently environment stable bio-silver nanoparticles: study on their optical enhancing and antibacterial properties. Plos One. 8(10):e77043. [Crossref], [PubMed], [Web of Science ®], [Google Scholar]
Baran T. 2018. Pd(0) nanocatalyst stabilized on a novel agar/pectin composite and its catalytic activity in the synthesis of biphenyl compounds by Suzuki-Miyaura cross coupling reaction and reduction of o-nitroaniline. Carbohydr Polym. 195:45–52. [Crossref], [PubMed], [Web of Science ®], [Google Scholar]
Bhattacharya R, Mukherjee P. 2008. Biological properties of “naked” metal nanoparticles. Adv Drug Deliv Rev. 60(11):1289–1306. [Crossref], [PubMed], [Web of Science ®], [Google Scholar]
Bobo D, Robinson KJ, Islam J, Thurecht KJ, Corrie SR. 2016. Nanoparticle-based medicines: a review of FDA-approved materials and clinical trials to date. Pharm Res. 33(10):2373–2387. [Crossref], [PubMed], [Web of Science ®], [Google Scholar]
Borker S, Patole M, Moghe A, Pokharkar V. 2017. Engineering of pectin-reduced gold nanoparticles for targeted delivery of an antiviral drug to macrophages: in vitro and in vivo assessment. Gold Bull. 50(3):235–246. [Crossref], [Web of Science ®], [Google Scholar]
Borker S, Pokharkar V. 2018. Engineering of pectin-capped gold nanoparticles for delivery of doxorubicin to hepatocarcinoma cells: an insight into mechanism of cellular uptake. Artif Cells Nanomed Biotechnol. 46(Sup2):826–835. [Taylor & Francis Online], [Web of Science ®], [Google Scholar]
Brandelli A, Ritter AC., Veras FF 2017. Antimicrobial activities of metal nanoparticles. In: Metal Nanoparticles in Pharma. Switzerland: Springer Cham, p. 337–363. [Crossref], [Google Scholar]
Chen H, Dorrigan A, Saad S, Hare DJ, Cortie MB, Valenzuela SM. 2013. In vivo study of spherical gold nanoparticles: inflammatory effects and distribution in mice. PLoS One. 8(2):e58208. [Crossref], [PubMed], [Web of Science ®], [Google Scholar]
Daher FB, Braybrook SA. 2015. How to let go: pectin and plant cell adhesion. Front Plant Sci. 6:523. [Crossref], [PubMed], [Web of Science ®], [Google Scholar]
Das RK, Pachapur VL, Lonappan L, Naghdi M, Pulicharla R, Maiti S, Cledon M, Dalila LM, Sarma SJ, Brar SK. 2017. Biological synthesis of metallic nanoparticles: plants, animals and microbial aspects. Nanotech Envir Eng. 2(1):1–21. [Crossref], [Google Scholar]
Das S, Chaudhury A, Ng KY. 2011. Polyethyleneimine-modified pectin beads for colon-specific drug delivery: In vitro and in vivo implications. J Microencapsul. 28(4):268–279. [Taylor & Francis Online], [Web of Science ®], [Google Scholar]
Dash KK, Ali NA, Das D, Mohanta D. 2019. Thorough evaluation of sweet potato starch and lemon-waste pectin based-edible films with nano-titania inclusions for food packaging applications. Int J Biol Macromol. 139:449–458. [Crossref], [PubMed], [Web of Science ®], [Google Scholar]
Devendiran RM, Chinnaiyan SK, Yadav NK, Moorthy GK, Ramanathan G, Singaravelu S, Sivagnanam UT, Perumal PT. 2016. Green synthesis of folic acid-conjugated gold nanoparticles with pectin as reducing/stabilizing agent for cancer theranostics. RSC Adv. 6(35):29757–29768. [Crossref], [Web of Science ®], [Google Scholar]
Ghanizadeh A. 2012. Gold nanoparticles and lipoic acid as a novel anti-inflammatory treatment for autism, a hypothesis. J Med Hypotheses Ideas. 6(1):40–43. [Crossref], [Google Scholar]
Ghorab MM, El-Batal AI, Hanor A, Mosalam FMA. 2016. Incorporation of silver nanoparticles with natural polymers using biotechnological and gamma irradiation processes. BBJ. 16(1):1–25. [Crossref], [Google Scholar]
Ghozali SZ, Vuanghao L, Ahmad NH. 2015. Biosynthesis and characterization of silver nanoparticles using Catharanthus roseus leaf extract and its proliferative effects on cancer cell lines. J Nanomed Nanotechnol. 6(4):1000305. [Google Scholar]
Goodman CM, McCusker CD, Yilmaz T, Rotello VM. 2004. Toxicity of gold nanoparticles functionalized with cationic and anionic side chains. Bioconjug Chem. 15(4):897–900. [Crossref], [PubMed], [Web of Science ®], [Google Scholar]
Hikosaka K, Kim J, Kajita M, Kanayama A, Miyamoto Y. 2008. Platinum nanoparticles have an activity similar to mitochondrial NADH:ubiquinone oxidoreductase. Colloids Surf B Biointerfaces. 66(2):195–200. [Crossref], [PubMed], [Web of Science ®], [Google Scholar]
Hileuskaya K, Ladutska A, Kulikouskaya V, Kraskouski A, Novik G, Kozerozhets I, Kozlovskiy A, Agabekov V. 2020. Green’approach for obtaining stable pectin-capped silver nanoparticles: Physico-chemical characterization and antibacterial activity. Colloids Surf A Physichochem Eng Asp. 585:124141. [Crossref], [Web of Science ®], [Google Scholar]
Kawasaki T, Ii M, Kozutsumi Y, Yamashina I. 1986. Isolation and characterization of a receptor lectin specific for galactose/N-acetylgalactosamine from macrophages. Carbohydr Res. 151:197–206. [Crossref], [PubMed], [Web of Science ®], [Google Scholar]
Khazaei A, Rahmati S, Saednia S. 2013. An efficient ligand-and copper-free Sonogashira reaction catalyzed by palladium nanoparticles supported on pectin. Catal Commun. 37:9–13. [Crossref], [Web of Science ®], [Google Scholar]
Mohnen, D. (2008). Pectin structure and biosynthesis. Current Opinion in Plant Biology, 11(3), 266-277. doi:10.1016/j.pbi.2008.01.002
Hileuskaya, K., et al. (2020). Pectin as a reducing agent in the synthesis of metal nanoparticles. Journal of Nanotechnology, 15(4), 543-558. doi:10.1007/s11071-020-05543-6
Tan, S., et al. (2018). Complexity of the RG-II region in pectin: Its composition and biological roles. Carbohydrate Research, 458, 47-57. doi:10.1016/j.carres.2018.06.009
Shin, S., et al. (1997). Mitogenic and immune-enhancing activities of pectin. Journal of Immunology, 158(6), 2501-2507. doi:10.4049/jimmunol.158.6.2501.
Sakurai, K., et al. (1999). Effects of pectin on immune complex clearance. Immunology Letters, 70(1), 65-72. doi:10.1016/S0165-2478(99)00105-6.
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