Level of Sex Hormone Binding Globulin (SHBG) in Sera of Iraqi Women with Polycystic Ovary Syndrome Correlating Infertility

Authors

  • Zahraa A.Sharhan Department of Chemistry, College of Science, Al-Nahrain University, Baghdad, Iraq
  • Suhad A. Ibrahim Department of Chemistry, College of Science, Al-Nahrain University, Baghdad, Iraq
  • Zahraa S. Al_Taie Department of Chemistry, College of Science, Al-Nahrain University, Baghdad, Iraq
  • Waled Abdo Ahmed Department of Chemistry, Faculty of Education, Dhamar University, Dhamar, 00967, Yemen
  • Rahimi M. Yusop Department of Chemical Sciences, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, UKM Bangi, Selangor, 43600, Malaysia

DOI:

https://doi.org/10.22401/

Keywords:

polycystic ovary syndrome, Primary infertility, sex hormone binding , insulin resistance, fasting blood sugar

Abstract

Ovulatory abnormalities are a prevalent cause of infertility in women, and they can result in PCOS, or polycystic ovary syndrome. This study aimed to evaluate and compare fasting blood sugar (FBS), insulin, insulin resistance (IR-OMO), sex hormone binding globulin (SHBG), and follicular, in addition to vitamin D3, stimulating hormone (FSH), testosterone (TT), estrogen (E2), luteinizing hormone (LH), prolactin (PRL), and the incidence of PCOS, associated with primary infertility in sera samples of Iraqi women. A total of 70 primary infertility women, and 30 apparently healthy controls were included in this study, their ages were ranged between 19 - 40 years. Blood samples were collected from patient in addition of healthy controls as (C group). The levels of FSH, LH, prolactin, TT, E2, IR-HOMO, and FBS were higher significantly (p˂0.001) in patient groups than C group. Results showed that serum levels of SHBG in patient (3.014±0.26 ng/ml) were decreased significantly in comparison with its levels (9.975 ±0.72 ng/ml) in sera sample of C group. On the other hand, vit. D3 levels of patients (11.78 ±1.41ng/ml) were also significantly decreased in comparison with C group (18.13 ±4.07ng/ml). Furthermore, it was found that there was non-significant positive correlation between serum levels of SHBG and LH, TT, E2, insulin, IR-HOMO, VITD3, and negatively associated with FSH, PRL and FSB in patients. Thus, it can be stated that the decreases of level SHBG were associated PCOS with primary infertility.

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Published

2025-03-15

Issue

Vol. 28 No. 1 (2025): March 2025

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Articles

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Copyright (c) 2025 Zahraa A.Sharhan, Suhad A. Ibrahim, Zahraa S. Al_Taie, Waled Abdo Ahmed, Rahimi M. Yusop

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How to Cite

(1)
Level of Sex Hormone Binding Globulin (SHBG) in Sera of Iraqi Women With Polycystic Ovary Syndrome Correlating Infertility. ANJS 2025, 28 (1), 14-19. https://doi.org/10.22401/.