Evaluating the Effect of the Ketogenic Diet on the Reproductive and Metabolic Parameters in Iraqi Females with Polycystic Ovary Syndrome
DOI:
https://doi.org/10.22401/Keywords:
Polycystic ovarian syndrome, Ketogenic diet , Metabilic syndrome , Insulin resistanceAbstract
Polycystic ovarian syndrome is the prevailing endocrine condition among females in their reproductive age. Clinically, it is characterized by irregular or delayed ovulation, excessive androgen levels, and the appearance of polycystic in ovaries. It is linked to a greater incidence of metabolic syndrome. Although it is related to various hereditary and environmental factors, insulin resistance is an essential factor in its development. The objective of our conducted research was to observe the impacts of the ketogenic diet on the reproductive and metabolic indicators in females who have been diagnosed with polycystic ovary syndrome. Eighty females of reproductive age have participated in the current investigation. During three months of adhering to the ketogenic diet, high statistical reductions (P=<0.0001) were investigated in body mass index (-5.4 Kg/m2), fasting blood sugar (-39.7 mg/dL), hemoglobin A1C (-1.03 %), insulin (-4.9 mIU/L), homeostatic model assessment for insulin resistance (-0.97), total testosterone (-0.29 ng/mL), luteinizing hormone (-6.9 mIU/ml), and LH/FSH ratio (-1.1). Conversely, highly statistical rises (P=<0.0001) were investigated in estradiol (29 pg/mL) and follicle-stimulating hormone (0.8 mIU/ml). The ketogenic diet and its advantageous impacts can serve as a supplementary treatment for polycystic ovarian syndrome.
References
[1] Anju, E.J.; Robert, J.N.; Elisabet, S-V.; Richard, S.L.; Stephen, F., Lisa, J.M.; et al.; “Polycystic ovary syndrome”. Lan. Diab. Endocrinol., 10(9):668-680,2022.
[2] Sydney, C.; Andera, M.D.; “Diagnosis of Polycystic Ovary Syndrome: which criteria to use and when?”. Endocrinol. Metab. Clin., 50(1):11-23,2021.
[3] Thomas, B.M.; Stephen, F.; “Obesity and polycystic ovary syndrome”. Clin. Endocrinol., 95(4):531-541, 2021.
[4] Xinyu, Z.; Xin, Y.; “Association between obesity and oligomenorrhea or irregular menstruation in Chinese women of childbearing age: a cross-sectional study”. Gynecol. Endocrinol., 36(12):1101–1105, 2020.
[5] Heather, G.H.; Anuja, D.; “Diagnosis and Treatment of Polycystic Ovary Syndrome”. JAMA, 327(3):274-275, 2022.
[6] Stephanie, C.; Siew, L.; Chelsea, A.; Stephanie, P.; Rebecca, T.; Melanie, G-H.; et al.; “Lifestyle management in polycystic ovary syndrome – beyond diet and physical activity”. BMC Endocr. Disord., 23:14, 2023.
[7] Erica, T.W.; Ivy, A.K.; Sanjiv, J.S; Martha, L.D.; Pamela, J.S.; Suma, H.K.; et al.; “Polycystic Ovary Syndrome Is Associated with Higher Left Ventricular Mass Index: The CARDIA Women's Study”. J. Clin. Endocrinol. Metab., 97(12):4656-4662, 2012.
[8] Antonio, P.; “Ketogenic Diet for Obesity: Friend or Foe?”. Int. J. Environ. Res. Pub. Heal., 11(2):2092-2107, 2014.
[9] Huiyuan, Z.; Dexi, B.; Youhua Z.; Cheng K.; Jiahao, D.; Xiawei, W.; et al.; “Ketogenic diet for human diseases: the underlying mechanisms and potential for clinical implementations”. Signal. Transduct. Target Ther., 7(1):11, 2022.
[10] Michael, R.; Kevin, D.H.; Juen, G.; Eric, R.; Laurel, S.M.; Marc, L.R.; et al.; “Glucose and Lipid Homeostasis and Inflammation in Humans Following an Isocaloric Ketogenic Diet”. Obesity (Silver Spring), 27(6): 971-981, 2019.
[11] Peter, J.F.; “Effect of low carbohydrate diets on insulin resistance and the metabolic syndrome”. Curr. Opin. Endocrinol. Diab. Obes., 28(5):463-468, 2021.
[12] Jacob, P.C.; Marcelle, I.C.; “Current Guidelines for Diagnosing PCOS”. Diagnostics (Basel), 13(6):1113, 2023.
[13] Nickerson, B.S.; Esco, M.R.; Fedewa, M.V.; Park, K.S.; “Development of a Body Mass Index-based Body Fat Equation: Effect of Handgrip Strength”. Med. Sci. Spor. Exerc., 52(11):2459-2465, 2020.
[14] Mari, A.; Ahrén, B.; Pacini, G.; “Assessment of insulin secretion in relation to insulin resistance”. Curr. Opin. Clin. Nutr. Metab. Care, 8(5):529-33, 2005.
[15] Kathleen, M.H.; Sharon, E.O.; “Do women with PCOS have a unique predisposition to obesity?”. Fertil. Steril., 97(1):13-17, 2012.
[16] Xin, Z.; Yuan-jie, X.; Ya-ting, L.; Shuang-lian, L.; Zhong-cheng, M.; “Polycystic ovarian syndrome: Correlation between hyperandrogenism, insulin resistance, and obesity”. Clin. Chim. Acta, 502:214-221, 2020.
[17] Maryam, K.; Amir, H.; Roger, A.P.; Marla, E.L.; Gordon, A.Z.; Philip, D.C.; “Effects of Dietary Glycemic Index and Glycemic Load on Cardiometabolic and Reproductive Profiles in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis of Randomized Controlled Trials”. Adv. Nutr., 12(1):161–178, 2021.
[18] Francesco, S.; Monica, S.; Giulio, D. M.; Giuseppe, B.; Giovanni, M.; Benedetta, T.; et al.; “Anabolic Androgenic Steroids: Searching New Molecular Biomarkers”. Front. Pharmacol., 9:1321, 2018.
[19] Antonio, P.; Laura, M.; Maria, C.G.; Antonio, C.; Massimiliano, C.; “Effects of a ketogenic diet in overweight women with polycystic ovary syndrome”. J. Transl. Med., 18:104, 2020.
[20] Jian, L.; Wen-Pei, B.; Bo, J.; Le-Ran, B.; Bei, B.; Shu-Xiang, Y.; et al.; “Ketogenic diet in women with polycystic ovary syndrome and liver dysfunction who are obese: A randomized, open-label, parallel-group, controlled pilot trial”. J. Obstet. Gynaecol. Res., 47(3):1145-1152, 2021.
[21] Skow, S.L.; Jha, R.K.; “A Ketogenic Diet is Effective in Improving Insulin Sensitivity in Individuals with Type 2 Diabetes”. Curr. Diab. Rev., 19(6):119-129, 2023.
[22] Aravind, R.K.; Meera, S.; Saketh, V.; Victoria, M.G.; Tamim, R.; Sanjeev, N.; et al.; “Ketogenic Diet: an Endocrinologist Perspective”. Curr. Nut. Rep., 8:402-410, 2019.
[23] Vincenzo, M.; Monica, S.; Moscatelli, F.; Ines, V.; Andrea, V.; Francesco, S.; et al.; “Role of Sex Hormones in the Control of Vegetative and Metabolic Functions of Middle-Aged Women”. Front. Physiol., 8: 773, 2017.
[24] Pierluigi, G.; Virginia, F.; Claudia, D.F.; Alessandra, G.; Antonio, M.; Paolo, S.; et al.; “Microbiome and PCOS: State-of-Art and Future Aspects”. Int. J. Mol. Sci., 22(4):2048, 2021.
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Copyright (c) 2025 Nazar Sattar Harbi, Alaa Hussein J. AL-Qaisi, Nany Hairunisa
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