Synthesis of Phenyl-1,3,4-Thiadiazol-2-Amine Derivatives with in-Vitro Antioxidant Activity

  • Yasameen K. Al-Majedy Branch of Chemistry, Department of Applied Science, University of Technology (UOT), Baghdad 10001, Iraq
  • Ali Mahdi Branch of Chemistry, Department of Applied Science, University of Technology (UOT), Baghdad 10001, Iraq
Keywords: 1,3,4-Thiadiazol thiosemicarbazide, 4- hydroxy coumarin, DPPH

Abstract

In this research, the synthesis of structurally important antioxidants 7-Hydroxy-4-Methyl Coumarin (C1) and 4- Hydroxy Coumarin derivatives was conducted. Coumarin was modified by various reaction steps for the production of target compounds. Different spectroscopic techniques characterized molecular structures FT-IR ,NMR. Antioxidant activity was carried out against 1,1-diphenyl-2-picrylhydrazyl (DPPH) in vitro spectrophometric assays. Compared to ascorbic acid, all compounds exhibited high antioxidant efficiency. Among compounds, Compound 9 performance was considered to be the highest (92%), followed by compounds 8 and 10 (90%). Ascorbic acid has been used as a standard drug with inhibition of the percentage 90.5%.

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Published
2020-06-04
How to Cite
K. Al-Majedy, Y., & Mahdi, A. (2020). Synthesis of Phenyl-1,3,4-Thiadiazol-2-Amine Derivatives with in-Vitro Antioxidant Activity. Al-Nahrain Journal of Science, 23(2), 33-38. Retrieved from https://anjs.edu.iq/index.php/anjs/article/view/2274
Section
Articles