A New Cyproheptadine PVC Ion Selective Electrode and their Applications in Pharmaceutical Preparations and Human Fluids

  • Yusur Q. Ismaeel Department of Chemistry, College of Science, Al-Nahrain University, Baghdad, Iraq
  • Bashaer A. Al-Phalahy Department of Chemistry, College of Science, Al-Nahrain University, Baghdad, Iraq
Keywords: Cyproheptadine, Bromophenol blue, Ion selective electrode, Pharmaceutical preparations, Human fluids

Abstract

A simple, sensitive and rapid method for the determination of Cyproheptadine in the pharmaceutical preparations and human fluids. The construction and electrochemical response characteristics of a poly vinyl chloride (PVC) membrane selective electrode for the determination of CPH are described. The proposed sensor was composed of cyproheptadine-Bromophenol blue as ion-exchanger and Di-butylphthalate (DBPH) (electrode A), Tris (2-ethylhexyl) phosphate (TEHP) (electrode B) and Ortho-nitrophenyloctylether (ONPOE) (electrode C) as plasticizers. The slopes were 53.10, 58.72 and57.44 mV/decade for electrode A, B and C. The linear ranges were 1×10-5 - 1×10-2, 5×10-5 -1×10-2 and 5×10-5 -1×10-2 M and the detection limits were 9×10-6,4.5×10-5 and 4×10-5 M for  Electrode A,B and C  respectively. The electrode B based on TEHP showed the best results. Electrodes were successfully applied to the determination of the cyproheptadine in tablets and human fluids by direct and standard addition potentiometry.

References

[1] Raghu, M. S.; Basavaiah, K.; "Application of Ion-Association Titration for the Assay of Cyproheptadine Hydrochloride in Pharmaceuticals"; ISRN Analyt. Chem. 2012, 1–7, 2012.
[2] Yang, C.; Men, Q.; "Determination of the content of cyperheptadine hydrochloride tablets by gas chromatography"; Yaowu Fenxi Zazhi 11(2), 113–118, 1991.
[3] Minaii, M.; Qomi, M.; Hoseini, S. S.; Sadri, A.; "Preconcentration and determination of cyproheptadine by using liquid phase microextraction and solvent bar in biological fluids in trace level", Biosci. Biotechnol. Res. Asia 12, 521–529, 2015.
[4] Feás, X.; Ye, L.; Hosseini, S. V.; Fente, C. A.; Cepeda, A.; "Development and validation of LC–MS/MS method for the determination of cyproheptadine in several pharmaceutical syrup formulations", J. Pharma. Biomed. Analysis 50(5), 1044–1049, 2009.
[5] El-Gindy, A.; El-Yazby, F.; Mostafa, A.; and Maher, M. M.; "HPLC and chemometric methods for the simultaneous determination of cyproheptadine hydrochloride, multivitamins, and sorbic acid", J. Pharma. Biomed. Analysis 35(4), 703–713, 2004.
[6] Al-Phalahy, B.A.; Rasheed, A.S.; "ICP Spectrometric–Vis Separation of Cerium (IV)–Desferal Complex Using 4-Vinylbenzyl-Dimethylammonio Pentanesulfonate Zwitterionic Stationary Phase"; Al-Nahrain J. Sci. 19, 25–32, 2016.
[7] Hussien, E.; Abdel-Gawad, F.; Issa, Y.; "Ion-selective electrodes for determination of fluoxetine in capsules and in biological fluids", Biochem. Eng. J. 53(2), 210–215, 2011.
[8] Davies, J.; Moody, G.; Price, W.; Thomas, J.; "Selective potassium-sensitive electrodes based on potassium tetra-p-chlorophenylborate-poly (vinyl chloride) sensor membranes", 4, 23-32, 1973.
[9] Umezawa, Y.; Bühlmann, P.; Umezawa, K.; Tohda, K.; and Amemiya, S.; "Potentiometric selectivity coefficients of ion-selective electrodes. Part I. Inorganic cations (technical report) ", Pure Appl. Chem. 72( 10), 1851–2082, 2000.
[10] Shakir, I. M.; Al-Phalahy, B. A.; "A novel online coupling of ion selective electrode with the flow injection system for the determination of vitamin B1" , Baghdad Sci. J. 13, 458–469, 2016.
[11] Ali, T. A.; Mohamed, G.G.; Yahya , G. A.; "Development of Novel Potentiometric Sensors for Determination of Lidocaine Hydrochloride in Pharmaceutical Preparations, Serum and Urine Samples", Iran J. Pharm. Res. 16, 498–512, 2017.
[12] Nassory, N. S.; Maki, S. A.; Al-Phalahy, B. A.; "Preparation and potentiometric study of promethazine hydrochloride selective electrodes and their use in determining some drugs", Turk. J. Chem. 32(5), 539–548, 2008.
[13] Vytr̆as, K.; "The use of ion-selective electrodes in the determination of drug substances"; J. Pharma. Biomed. Analysis 7(7), 789–812, 1989.
[14] Jasim, A. A.; "Three Simple Spectrophotometric Methods Using for Estimation of Vancomycin in Pure and Vial Injection", Al-Nahrain J. Sci. 23(1), 35–42, 2020.
Published
2020-06-04
How to Cite
Q. Ismaeel, Y., & A. Al-Phalahy, B. (2020). A New Cyproheptadine PVC Ion Selective Electrode and their Applications in Pharmaceutical Preparations and Human Fluids. Al-Nahrain Journal of Science, 23(2), 26-32. Retrieved from https://anjs.edu.iq/index.php/anjs/article/view/2273
Section
Articles