Synthesis, Characterization and Biological Activity of Some Heterocyclic Compounds Containing Quinoline Molecule
Keywords:
Quinoline, Pyrazole, Heterocyclic derivatives, AntibacterialAbstract
This work includes “organic” composition while biologically probe for several modern heterocyclic derivatives via 3 steps: Firstly synthesis from some 5-membered. heterocyclic derivatives (Pyrazole while isoindoline-1,3-dione) from quinoline. Secondly included characterized and confirmed by using melting point, TLC, infrared spectrum analysis while1H-NMR. Thirdly ncluded the examination of biological activity of some components against (4) varieties of pathogen bacteria (Staphylococcus aureus, Staphylococcus epidermidis) gram-positive and (Escherichia coli, Klebsiella sp.) gram-negative and fungal infections (Candida albicans). The results of whole derivatives show stellar biological activity compared to antibiotics (gentamycin).
References
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[2] Campaigne, E.; “Adrien Albert and the rationalization of heterocyclic chemistry”, J. Chem. Edu. 63 (10), 860, 1986.
[3] Banday, R. M.; Matto, H. R.; Rauf, A.;, “Synthesis, characterization and anti-bacterial activity of 5-(alkenyl)- 2-amino- and 2-(alkenyl)-5-phenyl-1,3,4-oxadiazoles”; J. Chem. Sci. 122 (2), 177–182 ,2010.
[4] Welsch, M. E., Snyder, S. A., Stockwell, B. R., Privileged scaffolds for library design &drug discovery, Curr. Opin. Chem. Biol., 14, 347-361, 2010.
[5] Warshakoon, C. N.; Sheville, J.; Bhatt, T. R.; Mendez, A. L. J.; Meyers, M. K.; Kim, N.; Wos, A. J.; Mitchell, C.; Jeennifer, L. P.; Benth, B. P.; Ofer, R.; Hu, X. E.; “Design and synthesis of substituted quinolines as novel and selective MCHA as antiobesity agents”; Bio-org. Med. Chem. Lett. 16, 5207-5211, 2006.
[6] Chen, Y. L.; Fang, K. C.; Sheu, J. Y.; Hsu, S. L.; Tzeng, C. C.; “Synthesis and antibacterialevaluation of certain quinolone derivatives”; J. Med. Chem. 44, 2374-2377, 2001 .
[7] Ashish, K. T.; Anil, M.; Verma, H. N.; Mishra, A.; “Synthesis and antifungal activity of 4-substituted-3,7-dimethyl pyrazolo[3,4-e] [1,2,4] triazine”; Ind. J. Chem. 45B, 489–492, 2006.
[8] El-Emary, T. I.; “Synthesis and biological activity of some new pyrazole[3,4-b]pyrazines”; J. Chin. Chem. Soc. 53, 391–401, 2006.
[9] Farghaly, T. A.; Abass, I. M.; Abdalla, M. M.; Mahgoub, R.; “Synthesis and pharmacological activities of fused pyrimidinones”; World J. Chem. 6, 8–18, 2011.
[10] Al-Bayati, R. I.; Ahmad, M. R.; Ahmed, L. S.; Am. J. Org. Chem. 5(4), 125-135, 2015.
[11] Loganathan, K.; Sithick, K.; Ali, M.; Purushothaman, S. S.; Jamal Abdul Nasser, A.; J. Chem. Pharm. Res. 7(4), 1452-1455, 2015.
[12] Mohammad, M. Y.; Mohammed, A. H.; Vinod, L. P.; Roma, K. P.; Rohit, H. D.; Int. J. Rec. Sci. Res. 9(4G), 26026-26030, 2018.
[13] Jafar, N. N.; Majeed, N. S.; “Microwave assisted synthesis of amide derivatives of the drug ciprofloxacin and screening the biological properties”; Int. J. Chem. Tech. Res. 9(7), 387-395, 2016.
[14] Ibraheem, H. H.; Al-Majedy, Y. K.; Salim, A. J.; Al-Bayati, R. I.; “Synthesis and Characterization of New 1,2-Dihydropyridine-3-Carbonitrile Compounds with Study of Expected Biological Activity”; Al-Nahrain J. Sci. 21(2), 45-50, 2018.
[15] Al-Bayati, R. I.; Hameed, S. M.; Ibraheem, H. H.; “Synthesis and Characterization of New Coumarin derivatives from Pyrazole derivatives”; Int. J. Appl. Nat. Sci. 4(6), 35-40, 2015.
[16] Sahu, S. K.; Banerjee, M.; Samantray, A.; Behera, C.; Azaml, M. A.; “Synthesis, Analgesic, Anti-inflammatory and Antimicrobial Activities of Some Novel Pyrazoline Derivatives”; Trop. J. Pharma. Res. 7 (2), 961-968, 2008.
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Published
2020-03-04
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[1]
“Synthesis, Characterization and Biological Activity of Some Heterocyclic Compounds Containing Quinoline Molecule”, ANJS, vol. 23, no. 1, pp. 1–6, Mar. 2020, Accessed: Apr. 26, 2024. [Online]. Available: https://anjs.edu.iq/index.php/anjs/article/view/2234
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