Synthesis, Characterization and Biological Activity of Some Heterocyclic Compounds Containing Quinoline Molecule

  • Sarah Abdulhamza Hameed Chemistry Division, Department of Applied Science, University of Technology, Baghdad-Iraq
  • Hiba H. Ibraheem Chemistry Division, Department of Applied Science, University of Technology, Baghdad-Iraq
Keywords: Quinoline, Pyrazole, Heterocyclic derivatives, Antibacterial

Abstract

This work includes “organic” composition while biologically probe for several modern heterocyclic derivatives via 3 steps: Firstly synthesis from some 5-membered. heterocyclic derivatives (Pyrazole while isoindoline-1,3-dione) from  quinoline. Secondly included characterized and confirmed by using melting point, TLC, infrared spectrum analysis while1H-NMR. Thirdly ncluded the examination of biological activity of some components against (4) varieties of pathogen bacteria (Staphylococcus aureus, Staphylococcus epidermidis) gram-positive and (Escherichia coli,  Klebsiella sp.) gram-negative and fungal infections (Candida albicans). The results of whole derivatives show stellar biological activity compared to antibiotics (gentamycin).

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Published
2020-03-04
How to Cite
Abdulhamza Hameed, S., & H. Ibraheem, H. (2020). Synthesis, Characterization and Biological Activity of Some Heterocyclic Compounds Containing Quinoline Molecule. Al-Nahrain Journal of Science, 23(1), 1-6. Retrieved from https://anjs.edu.iq/index.php/anjs/article/view/2234
Section
Articles