Synthesis and Characterization of New 1,2-Dihydropyridine-3-Carbonitrile Compounds with Study of Expected Biological Activity

Authors

  • Hiba H Ibraheem Chemistry division, Department of applied science, University of Technology, Baghdad-Iraq
  • Yasameen K Al-Majedy Chemistry division, Department of applied science, University of Technology, Baghdad-Iraq
  • Ali J Salim Department of Chemistry, College of Science, Al-Mustansiriya University, Baghdad-Iraq.
  • Redha I Al-Bayat Department of Chemistry, College of Science, Al-Mustansiriya University, Baghdad-Iraq.

Keywords:

1,2-Dihydropyridine, 2 H-Chromen-2-One

Abstract

New 1,2-dihydropyridine-3-carbonitrile derivative compounds (3,4) were synthesized by cyclization of ketones (compound (1) and compound (2)) with appropriate aldehydes (4-N, N-dimethylaminobenzaldehyde and 4-chloro-2-oxo-2H-chromene-3-carbaldehyde) in presence of ethyl cyano acetate and ammonium acetate. The new synthesized compounds have been characterized using Melting point, FT-IR spectroscopy and 1H-NMR and 13C-NMR spectrum. The evaluation of biological activity of some synthesized compounds (1-4) with different concentration 10 mg mL−1, 1 mg mL−1 and 0.1 mg mL−1, against two types of bacteria on gram positive bacterial Staphylococcus aureus, Streptococcus pyogenus and gram nagetive bacterial Escherichia coli, Klebsiella pneumniae.

 

Published

2018-09-24

Issue

Section

Articles

How to Cite

(1)
Synthesis and Characterization of New 1,2-Dihydropyridine-3-Carbonitrile Compounds With Study of Expected Biological Activity. ANJS 2018, 21 (2), 45-50.