PREPARATION AND STUDY OF AMOXICILLIN SELECTIVE ELECTRODES AND THEIR APPLICATION WITH DERIVATIVE SPECTROPHOTOMETER IN PHARMACEUTICAL DRUGS

Authors

  • Khaleda H Al-Saidi Al-Nahrain University, College of Science, Chemistry Department, Al-Jaderia, Baghdad, Iraq
  • Nabil S Nassory Al-Nahrain University, College of Science, Chemistry Department, Al-Jaderia, Baghdad, Iraq
  • Shahbaz A Maki Al-Nahrain University, College of Science, Chemistry Department, Al-Jaderia, Baghdad, Iraq

Keywords:

Amoxicillin electrodes, Phosphotungstic acid ionophore, Derivative spectrophotometer, Amoxicillin determination

Abstract

Amoxicillin trihydrate selective electrodes were prepared based on amoxicillin-phosphotungstate (Amox-PT) as an active sensor with different plasticizers, di-butyl phosphate (DBP), di-butyl phthalate (DBPH), di-octyl phthalate (DOPH), tri-butyl phosphate (TBP) and o-nitro phenyl octyl ether (NPOE) in PVC matrix membranes. The study was carried out to investigate the electrode parameters, effect of pH, selectivity and UV-derivative spectrophotometer technique. Internal filling solution of 10-3 M + 10-3 M NaCl was used to fill the electrodes. The best electrode was based on DBP plasticizer which gave a slope 58.7 mV/decade and detection limit of 2 x 10-6 M displayed good stability and reproducibility. The electrode was used to determine the amoxicillin in oral suspension and capsules. The results were compared with UV-derivative spectrophotometer technique and the recovery for the drugs obtained by second derivative are quite comparable with the recovery obtained by amoxicillin electrodes.

 

Published

2009-03-01

Issue

Section

Articles

How to Cite

(1)
PREPARATION AND STUDY OF AMOXICILLIN SELECTIVE ELECTRODES AND THEIR APPLICATION WITH DERIVATIVE SPECTROPHOTOMETER IN PHARMACEUTICAL DRUGS. ANJS 2009, 12 (1), 29-37.

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