COLORIMETRIC ASSAY OF ASPIRIN USING MODIFIED METHOD

  • Maadh Qusay Abdulkadir Department of Pharmaceutical Chemistry, College of Pharmacy, University of Baghdad-Iraq.
  • May Mohammed Jawad Al-Mudhafar Department of Pharmaceutical Chemistry, College of Pharmacy, University of Baghdad-Iraq.
  • Amera Abbas Mohammed Department of Pharmaceutical Chemistry, College of Pharmacy, University of Baghdad-Iraq.
  • Suha K Alzahawie Department of Pharmaceutical Chemistry, College of Pharmacy, University of Baghdad-Iraq.
Keywords: Ferric chloride, hydrolysis, absorbance

Abstract

In this research, we did this qualitative and quantitative study in order to improve the assay of aspirin colorimetrically using visible spectrophotometer. This method depends on aqueous hydrolysis of aspirin and then treating it with the ferric chloride acidic solution to give violet colored complex with salicylic acid, as a result of aspirin hydrolysis, which has a maximum absorption at 530nm. This procedure was applied to determine the purity of aspirin powder and tablet. The results were approximately comparative so that the linearity was observed in the high value of both correlation coefficient (R = 0.998) and Determination Coefficient or Linearity (R2 = 0.996) while the molar absorpitivity was 1.3´103 mole-1.L.cm-1. This improvement cancelled the acid or base aided hydrolysis which is widely used during aspirin assay. This method could be also applied to salicylic acid.

 

Published
2009-09-01
How to Cite
Abdulkadir, M. Q., Al-Mudhafar, M. M. J., Mohammed, A. A., & Alzahawie, S. K. (2009). COLORIMETRIC ASSAY OF ASPIRIN USING MODIFIED METHOD. Al-Nahrain Journal of Science, 12(3), 1-7. Retrieved from https://anjs.edu.iq/index.php/anjs/article/view/1197
Issue
Vol 12 No 3 (2009): September
Section
Articles
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