STUDYING THE INHIBITORY EFFECTS OF ACETAMINOPHEN (PARACETAMOL), AND SALICYLATE DRUG (ASPEGIC) ON THE ACTIVITY OF CREATINE KINASE

Authors

  • Perry H Ali Department of Biochemistry Chemistry, College of Sciences for Women, University of Baghdad.
  • Jinan Husain Department of Biochemistry Chemistry, College of Sciences for Women, University of Baghdad.
  • Jinan Husain Department of Biochemistry Chemistry, College of Sciences for Women, University of Baghdad.
  • Iman Hashim Department of Biochemistry Chemistry, College of Sciences for Women, University of Baghdad

Keywords:

NON

Abstract

We have studied for the first time in Iraq, the effect of aspegic and paracetamol on the activityof creatine kinase in the sera of 25 premenopausal health women our results revealed that inthe presences of increasing concentrations of aspegic and paracetamol the activity of creatinekinase is inhibited and the inhibition is concentration dependant and independent respectively.The kinetic parameter of creatine kinase was measured (Vmax= 133.3.00 IU/L,Km=(2.13 } 0.2 mM).Aspegic act as reversible competitive inhibitor for CK(150 } 3.3 IU/L ,Km= 2.4 } 0.4mM) and paracetamol act as reversible uncompetitive inhibitor for creatine kinase(87.72 } 2.1 IU/L, Km=2.02 } 0.33 Mm).

 

 

Published

2010-06-01

Issue

Section

Articles

How to Cite

(1)
STUDYING THE INHIBITORY EFFECTS OF ACETAMINOPHEN (PARACETAMOL), AND SALICYLATE DRUG (ASPEGIC) ON THE ACTIVITY OF CREATINE KINASE. ANJS 2010, 13 (2), 63-68.