Preparation of Some 1,2,4-Triazol Schiff Bases as Urease Inhibitors and Study Their Effect on Proteus Mirabilis Bacteria
Keywords:
triazol ring, triazol Schiff base, urease inhibitorsAbstract
The basic nucleus 4-(amino)-5-phenyl-l-4H-1,2,4-triazole-3-thiol was prepared by cyclisation of potassium dithiocarbazinate with hydrazine hydrate using ethanol as solvent under reflux condition for 3-4 hrs.. The compound which has been synthesized successfully was subjected to addition reaction with different aldehydes to synthesize Schiff bases. The compounds were confirmed by[ physical parameters (solubility, melting point),1H nuclear magnetic resonance (1HNMR)and spectroscopic methods (FTIR)]. All the synthesized compounds were screened for their urease inhibition. Some compounds showed excellent urease inhibition activity.
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2018-06-24
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[1]
“Preparation of Some 1,2,4-Triazol Schiff Bases as Urease Inhibitors and Study Their Effect on Proteus Mirabilis Bacteria”, ANJS, vol. 17, no. 4, pp. 44–50, Jun. 2018, Accessed: Apr. 19, 2024. [Online]. Available: https://anjs.edu.iq/index.php/anjs/article/view/376