Synthesis and Evaluation the Activity of 1, 3, 4-Thiadiazole Derivatives as Antibacterial Agent Against Common Pathogenic Bacteria

  • Evon Akram Department of Chemistry, College of Science, Al-Nahrain University, Baghdad-Iraq.
  • Shaymaa Naji Daham Department of Biology, College of Education, Samarra University, Samarra-Iraq.
  • Alaa Adnan Rashad Department of Chemistry, College of Science, Al-Nahrain University, Baghdad-Iraq.
  • Asmaa Easa Mahmood Department of Pathological Analyzes, College of Applied Sciences, Samarra University, Samarra-Iraq.
Keywords: Synthesis, 1, 3, 4-thiadiazole, antibiotic, antibacterial

Abstract

Schiff base compound 5-(benzylideneamino)-1,3,4-thiadiazole-2-thiol was prepared from condensation reaction of 2-amino-5-mercapto-1,3,4-thiadiazole with benzaldehyde. Schiff bases react with Copper(ӀӀ), Ferric(ӀӀӀ), Cobalt(ӀӀ) and Zinc(ӀӀ) to form four complexes. The Schiff base complexes were identification by using FTIR and UV-VIS. The antibacterial activity of complexes (Copper(ӀӀ), Ferric(ӀӀӀ), Cobalt(ӀӀ) and Zinc(ӀӀ)) were studied against S. aureus  and S . epidermidis as a model of Gram positive, E. coli, P. mirabilis, C. freundii and P. aeruginosa as a Gram negative model to determine activity of synthesized complexes, after subjected them to some tests to confirm the identity of the pathogenic bacteria. Ten antibiotics (Ampicillin and Amoxicillin) have been chosen to investigate the ability of bacterial isolates to resistant the conventional antibiotic. Imipenem have been selected to contrast its efficiency with those of the new compounds because of its high efficiency. The results exhibited higher activity of the new compounds proportional to the chosen antibiotics.

Published
2019-03-01
How to Cite
Akram, E., Daham, S., Rashad, A., & Mahmood, A. (2019). Synthesis and Evaluation the Activity of 1, 3, 4-Thiadiazole Derivatives as Antibacterial Agent Against Common Pathogenic Bacteria. Al-Nahrain Journal of Science, 22(1), 25-32. Retrieved from http://anjs.edu.iq/index.php/anjs/article/view/2090
Section
Articles